タンパク質治療

Therapeutic protein drugs are an important class of medicines serving patients most in need of novel therapies. Applications in this therapeutic class include the bioprocessing of
• Monoclonal antibodies
• Antibody fragments
• Fc and Albumin fusions
• Blood factors
• Protein-based vaccines

Trends in Protein Therapeutic bioprocessing

Recently approved recombinant protein therapeutics have been developed to treat a wide variety of clinical indications, including cancers, autoimmunity/inflammation, exposure to infectious agents, and genetic disorders.

Protein therapeutics development and manufacturing is a highly complex process. In both process development as well as commercial manufacturing, the protein therapeutics workflow includes cell optimization, cell culture, harvest, purification, formulation and fill and finish.

Since the products are synthesized by living cells or organisms, the choices of cell line and cell culture conditions all affect the final product characteristics, and complex purification processes are involved using filters and resins to produce the final product.