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Continuous Bioprocessing: Industry Best Practices

E-book Volume 2
February 2018

Compiled by John Bonham-Carter, Repligen

Chapters

  1. Introduction to Continuous Bioprocessing: Current Status and Trends
    Eric S. Langer, BioPlan Associates, Inc. and and Ronald A. Rader
  2. How to Develop a Perfusion Process
    Véronique Chotteau, Royal Institute of Technology (KTH)
  3. Strategies for development of perfusion media
    Delia Lyons, MilliporeSigma and Jochen Sieck, Merck KGaA
  4. Perfusion Application in Mobius® Single-use Bioreactors
    Michael Cunningham and Douglas Rank, MIlliporeSigma
  5. XCell ATF® Perfusion Technology Delivers High Throughput: Efficient Seed Train Process with Improved Fed-Batch Production Output
    W. Roy Lin, Shashi Kudugunti, Mario Sinani, Tim Erlandson and Dr. James Rusche, Repligen
  6. Product Quality Considerations of Perfusion Processes
    Thomas Villiger, Daniel Karst and Massimo Morbidelli, ETH Zurich
  7. Impurity Monitoring as Novel PAT Tool for Continuous Biopharmaceutical Processes
    Vignesh Rajamanickam, Dr. Patrick Sagmeister, Oliver Spadiut, and Christoph Herwig, TU Wien Austria
  8. Insect Cells and ATF
    Willem Adriaan (Wian) de Jongh, PhD, ExpreS2ion Biotechnologies
  9. Scale up and Technology Transfer in a Continuous Processing Environment
    Sadettin S. Ozturk, Ph.D., Massbiologics
  10. Continuous Multicolumn Chromatography Processes
    Marc Bisschops, Pall Corporation
  11. Impact of Single‑use Technology on Continuous Bioprocessing
    William G. Whitford, GE Healthcare
  12. Continuous Bioprocessing's Impact on Facility Design
    Morten Munk, NNE A/S

 

     Download E-Book Volume 2

Continuous Bioprocessing: Current Practice and Future Potential

E-book Volume 1
2014

Compiled by John Bonham-Carter, Repligen

Chapters

  1. Introduction to Continuous Manufacturing:Technology Landscape and Trends
    Eric S. Langer and Ronald A. Rader, BioPlan Associates
  2. A Brief History of Perfusion Biomanufacturing
    Jerry Shevitz and John Bonham-Carter, Refine Technology
  3. Bioreactor Configuration and Operation
    Christel Fenge, Jörg Weyand, Gerhard Greller, Thorsten Adams, Sartorius Stedim Biotech
  4. How to Develop a Perfusion Process
    Véronique Chotteau, Royal Technical University, KTH
  5. Case Study: Optimized Perfusion
    Shaun Eckerle, Gallus BioPharmaceuticals
  6. Process Intensification Approaches for Cost Sensitive Protein Applications
    Willem Adriaan de Jongh, Expres2ion Biotechnologies
  7. Impact of Single-use Technology on Continuous Biorocessing
    William G. Whitford, Thermo Fisher Scientific
  8. Continuous Multicolumn Chromatography Processes
    Marc Bisschops, Tarpon Biosystems
  9. Continuous Processes: Economic Evaluation
    Andrew Sinclair and Andrew Brown, BioPharm Services
  10. Vision: Integrating Upstream and Downstream in a Fully Continuous Facility
    Tim Johnson, Genzyme

 

      Download e-book Volume 1

技術ノート、アプリケーションノート

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ホワイトペーパー

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AAV Studies Deploying a Closed, Irradiated, Single-use Flat Sheet TFF Device

by David Bianchi, Carl Breuning, Michael LaBreck, Shelly Parra, Mary Jo Wojtusik, Repligen Corporation 
Alex Meola, Michael Mercaldi, Thomas Thiers, Homology, Medicines Inc. 

Repligen Corporation
Homology, Medicines Inc.
July 2020

選択されたサードパーティのリファレンス

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TFDF™テクノロジーを利用してレンチウイルスベクター生産プロセスを強化する
Thomas Williams、Oliver Goodyear、Lee Davies、Carol Knevelman、Michael Bransby、Kyriacos Mitrophanous、James Miskin
Cell and Gene Therapy Insights、2020年4月

Special Report on Continuous Bioprocessing: Upstream, Downstream, Ready for Prime Time?
by Angelo DePalma
BioProcess International, May 2016

Continuous Manufacturing: A Changing Processing Paradigm
By Randi Hernandez
BioPharm International, Apr 01, 2015

A Novel Seed-Train Process: Using High-Density Cell Banking, a Disposable Bioreactor, and Perfusion Technologies
by Benjamin Wright, Mike Bruninghaus, Mike Vrabel, Jason Walther, Neha Shah, Seul-A Bae, Timothy Johnson, Jin Yin, Weichang Zhou and Konstantin Konstantinov
BioProcess International, March 2015

Developing an Integrated Continuous Bioprocessing Platform: Interview with Konstantin Konstantinov 
by Maribel Rios
BioProcess International, December 2012

A Brief History of Perfusion Biomanufacturing: How High-Concentration Cultures Will Characterize the Factory of the Future
by John Bonham-Carter and Jerry Shevitz
BioProcess International, October 2011

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