Traditional custom affinity resin development methods start with one scaffold, explore limited ligand sequence space and struggle to deliver consistent results, ultimately requiring multiple iterations that extend the overall timeline. By starting with more than 50 multifarious scaffolds, Repligen generates unprecedented library diversity to achieve high binding capacity, selectable pH requirements and caustic stability on the first iteration at an unparalleled success rate.
AAV affinity resins provide one-step purification of adeno-associated virus (AAV) 2,8 and 9 vectors with potential alkaline clean-in-place regeneration for improved process economics. A 50 µm cross-linked agarose matrix bead ensures compatibility with standard bioprocess columns and flowrates (3 bar at 300 cm/hour).
NGL COVID-19 Spike Protein Affinity Resin binds the SARS-CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. The resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid implementation as well as in loose resin formats.