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NGL COVID-19 Spike Protein Affinity Resin

Novel SARS CoV-2 specific affinity resin enables a high purity capture step, decreased process time, and yield improvement for the commercial production of COVID-19 vaccines.

Icon_NEW.jpg sars CoV-2 Specific affinity Resin

for the purification of COVID-19 vaccines

Novel affinity resin for the purification of the SARS CoV-2 Spike Protein for vaccine development and manufacturing

The result of close work with Navigo Proteins on the ligand development and partnership with Purolite Life Sciences on Praesto® agarose bead technology, the new NGL COVID-19 Spike Protein Affinity Resin from Repligen binds the SARS CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. The product meets all the expected requirements of a high-performance resin, including very high selectivity, high dynamic binding capacities and caustic stability over multi-cycle use.

The resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid implementation as well as in loose resin formats.

Single-step affinity chromatography with high resolution

NGL COVID-19 Spike Protein Affinity Resin key features include:

  • Single-step purification of SARS-CoV-2 spike protein RBD containing modalities*
  • Compatible with 0.1N NaOH for CIP
  • High binding capacity **
* Targets SARs CoV-2 spike protein variants containing the RBD. Examples include: S protein (S1/S2), S1 Protein, RBD, S Protein Trimer. Development data suggest that purification of whole inactiviated virus, virus like particles (VLPs), and adenovirus may not yield satisfactory results.
**Actual DBC dependent on S protein variant & size

optimized bead chemistry delivers exceptional purity

NGL COVID-19 Spike Protein Affinity Resin delivers >90% purity in one chromatography step.

SDS-PAGE gel of the SARS-CoV-2 Spike protein Receptor Binding Domain (RBD) expressed in HEK293 cells and purified with NGL COVID-19 Spike Protein Affinity Resin.  

Available Pre-packed in OPUS® Columns for quick deployment

 

The NGL COVID-19 Spike Protein Affinity Resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid GMP implementation as well as in loose resin formats.

OPUS® Columns allow you to progress from development to manufacturing scale in weeks, using pre-packed and pre-qualified chromatography columns.

About OPUS® Columns