TangenX PROリユーザブル

Designed to be cleaned and re-used multiple times, TangenX^® PRO and PRO PD Reusable TFF Cassettes are interchangeable with SIUS^® Single-use TFF Cassettes.

見積を請求

TangenX^® PRO REUSABLE TFF CASSETTES

TangenX^® PRO Reusable Tangential Flow Filtration (TFF) Cassettes may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.

Validated for GMP use, TangenX^® PRO Reusable TFF Cassettes come in two industry standard format footprints with accompanying holders. They are available using ProStream or HyStream membranes, with choice of pore size and flow-channel configuration.

交換可能

with TangenX^® SIUS^® Single-use TFF Cassettes - same channel geometry, same membrane chemistry

スケーラブル

プロセス開発から商業規模まで

コスト削減

他のリユーザブルTFFフラットシートフィルターカセットよりも低コスト（最大で30%の削減）

高い安定性

エアインテグリティと流体力学的性能の厳しいQCロットリリーステスト

互換性

主要サプライヤー（Millipore社、Pall社、Sartorius社）製ホルダーに対応

GMP向けに検証済み

規制ガイドラインに準拠する検証ガイドとコンプライアンス証明書を提供

TangenX^® PRO PD FOR PROCESS DEVELOPMENT

During process development, scientists aim to select the most promising membrane candidates, while making related decisions regarding feed pressure, TMP and screen geometry. TangenX^® PRO PD Reusable TFF Cassettes enable process development scientists to select the most promising membrane candidates.

To ensure fit with cassette holders from other manufacturers, TangenX^® PRO PD Reusable TFF cassettes are offered with two different notch patterns at the end of the cassette.

メンブレン
表面積

0.01 m²
0.02 m²
0.10 m²

TangenX^® PRO PD with standard notch
0.850インチ（21.59mm）オフセット

このフォーマットは以下のカセットホルダーに適合します。

TangenX^® PRO PDカセットホルダー
Pall - Centramateホルダー（CM018LV、FS001K10）

TangenX^® PRO PD with offset notch
0.756インチ（19.21mm）オフセット

このフォーマットは以下のサードパーティ製カセットホルダーに適合します。

Sartorius - Sartocon Sliceホルダー（17525-01、17521-02）
GE - Kvick Labホルダー（KLPH01SSU、KLHR0105000SS）
Millipore - Pelliconミニホルダー（XX42PMINI）

TangenX^® PRO FOR SCALE-UP AND COMMERCIAL MANUFACTURING

メンブレン
表面積

0.5 m²
1.5 m²
2.5 m²

When the primary membrane candidate has already been chosen as a process parameter, the production method needs to be verified and production materials produced for toxicology or pre-clinical trials, and ultimately for large-scale commercial production. TangenX^® PRO Reusable TFF Cassettes provide reliable cassette-to-cassette consistency, ensuring that processes can scale to commercial production levels.

プロセス開発から商業規模までスケーラブルに対応

Process volume and membrane area determine scale-up from TangenX^® SIUS^® Single-use Cassettes to TangenX^® PRO Reusable TFF Cassettes.

シングルユースTFFは小規模から中規模の運用に最大のメリットを提供
リユーザブルTFFは大規模な運用に最適
シングルユースTFFは医薬品製造受託機関に最適

Repligenの担当者に問い合わせて、お客様の用途におけるコストモデルをシュミレートしてください。

複数チャンネル構成

Tangential flow filtration cassettes create turbulence at the membrane's surface and minimize fouling . The result is an increase in performance with a higher permeate flux. The TangenX^® PRO reusable cassettes are offered in three different channel configurations to best suit the application. The channel configuration refers to the type of turbulence promoter incorporated into the feed channel of a cassette.

H Screen - A fine channel or "H" screen is offered in all TangenX^® PRO cassettes and creates the most turbulence at the membrane's surface ensuing exceptional permeate flux with minimal fouling. This type of turbulence promoter requires the lowest pumping rate and yields the highest cross flow velocity of all three types offered. It also has the highest pressure drop (Delta P) and is easily plugged with small particulates. This type of channel is best suited for dilute feed streams free of particulates with a lower viscosity.

L Screen - A medium channel or L screen is offered in all TangenX^® PRO cassettes and creates a more moderate amount of turbulence at the membrane's surface with minimal fouling. This type of turbulence promoter requires a higher pumping rate than the H screen in order to match the cross flow velocity. When operating at the recommended cross flow rate, it will have a 50% lower pressure drop (Delta P) than the H screen. This type of channel is best suited for clarified feed streams with a moderate to high viscosity.

Suspended Screen - A suspended screen or S channel is offered in all TangenX^® PRO cassettes and consists of a screen suspended over the surface of the membrane using flow spacers. This type of channel creates the least amount of turbulence at the membrane's surface while still minimizing fouling. It also requires the highest pumping rate and can not match the cross flow velocity of the screen channel cassettes. It does however have the ability to pass particulates, such a cells or cell debris through the channel without plugging. This type of channel is best suited for unclarified feed streams or ones with a very high viscosity.