KrosFlo® RS TFF Systems
WHEN EVERY DROP COUNTS
Ideal for mRNA and gene therapy solutions, KrosFlo® RS TFF Systems are engineered for maximum recovery. The combination of injection molded tubing, over-molded connections, and valve blocks significantly lowers hold-up volume.
WHEN EVERY DROP COUNTS
For mRNA, AAV, Lentivirus developers
Minimize hold-up volume with innovative valve block technology
Intelligent mixing even at the lowest working volume
ZERO MANUAL INTERVENTION
Automate from sanitization to recovery
Eliminate batch variation with end-to-end automation
READY TO SCALE FAST
For effortless scaling from 1/4" to 1"
Maintain processes while scaling to production
1滴1滴が大切
Minimize hold-up volume with innovative valve block technology
Ideal for mRNA and gene therapy solutions, KrosFlo® RS TFF Systems are engineered for maximum recovery.
The combination of injection molded tubing, over-molded connections, and valve blocks significantly lowers hold-up volume.
1滴1滴が大切
Intelligent mixing even at the lowest working volume
Innovative tulip tank technology delivers hold-up volumes as low as 1.5L with active mixing.
As fluid levels drop, the dual impellers independently adjust speed to reduce harmful surface interaction while automated valves adapt retentate flow to avoid damage upon entering the tank.
Tulip Tank cart available with KrosFlo® RS 30, 40, 50
ZERO MANUAL INTERVENTION
Eliminate batch variation with end-to-end automation
Completely automate processes from start to finish without intervention.
Traditional single-use systems require manual manipulation due to the limited number of controlled valves. Additional controlled valves throughout the flowpath allow complete automation of processes.
Sanitization
- WFI/Buffer Flushing
- Integrity testing
Concentration
- Fed-Batch Concentration
- Batch Concentration
Recovery
- Product Recovery
- Clean-in-place
READY TO SCALE FAST
Maintain processes while scaling to production
KrosFlo® RS 20
0.1 - 0.5 m²
KrosFlo® RS 30
0.5 - 3 m²
KrosFlo® RS 40
1 – 5 m²
KrosFlo® RS 50
5 – 10 m²
Industrial grade components and extended automation allow for confident process scaling. With the same software, hardware, controls and cGMP compliance built into every system, process change challenges in scale-up are removed.
KrosFlo® RS TFF Systems
KrosFlo® RS Single-use Tangential Flow Filtration (TFF) Systems incorporate the most advanced engineering principles to achieve unprecedented automation, hold-up volume and process control. The unique tulip tank continuously measures sample volume and then adjusts dual impeller speeds and retentate routing to nearly eliminate foaming. Conceptualized as a platform, rather than a single system, a single architectural approachenables effortless scale-up from 1/4" to 1".
Click on the tabs to explore features of the different KrosFlo RS Systems.
KrosFlo® RS 20 TFF System
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KrosFlo® RS 30 TFF System
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KrosFlo® RS 40 TFF System
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KrosFlo® RS 50 TFF System
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Error-free installation in minutes with pre-assembled flow paths
ProConnex Flow Paths, pre-assembled and specific to the KrosFlo® RS TFF System, are intuitively designed for simple, mistake-free installation. All system sensors are pre-calibrated and assembly is done in minutes with no confusing instructions.
Click on the left/right arrows or swipe to see flow path assembly steps for the different KrosFlo® RS TFF Systems.
The world's most advanced TFF systems
In an era of new modalities, developers are striving to maximize efficiency.
The new KrosFlo® RS TFF systems by Repligen empower users through maximized recovery, full automation and effortless scaling.
Manufacturing Centers of Excellence
Repligenは、ISO 9001品質管理システムに基づいて、バイオ医薬品業界向けの製品を開発・製造しています。高品質で安定した、堅牢な製品をタイムリーに提供し、お客様の事業継続性を保証することを重視しています。
Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands, Germany and Estonia.
Expert Project Management
お客様第一。
サポートは、Repligenという企業の遺伝子に組み込まれています。弊社の目標は、卓越した顧客体験を提供すること、そしてRepligenの製品やサービスの適用や導入を効率よく成功に導くためにサポートすることです。
- Field Application Support
- カスタマーサービス
- フィールドサービスエンジニア
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ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
