KrosFlo® FS TFF Systems
Fully automate flat sheet TFF processes up to 500 L with configurable hardware components that deliver an unparalleled combination of automation, configurability, simplicity and compliance.
スケーラブル
Scale from Lab to Pilot manufacturing
integrated
Modular, plug-and-play hardware with diaphragm pump
The KrosFlo® FS Systems achieve an unparalleled combination of configurability and automation and compliance for flat sheet TFF processes. All components, either directly or indirectly, connect to the main KrosFlo® FS diaphragm pump, which then communicates with the KF Comm 2 software for control and monitoring.
- 濃縮（C）や透析ろ過（D）などのシンプルなアプリケーションのための最小限のコンポーネントを構成
- 分取（F）や多段階プロセス（CDC/D/Cなど）のためのプラグアンドプレイ追加コンポーネント
Click on the tabs below to explore different combinations of concentration and diafiltration configurations using the KrosFlo® FS TFF System.
C = Concentration D = Diafiltration F = Feed
Add a scale and auxiliary pump to access diafiltration applications
C = Concentration D = Diafiltration F = Feed
Build process understanding with increased sensors
C = Concentration D = Diafiltration F = Feed
integrated
ProConnex® Flow Paths for FS Systems
Save time, streamline operations and hit the ground running
These ready-to-go flow paths create time and quality gains for every run. Enjoy the affordable convenience of off-the-shelf flow paths designed by the engineers who created the system you adore. These are created specifically to run TangenX® flat sheet cassettes on the KrosFlo® FS systems. Filter sold separately.
integrated
専用ボードによる
双方向のデータ転送
メインのKrosFlo® FSシステムのポンプには、マイクロプロセッサーベースの先進的なコントローラーが内蔵されており、ハードウェアコンポーネントのプラグアンドプレイを可能にしています。KF Comm 2ソフトウェアと、自動背圧制御バルブ、測定器、補助ポンプ、Konduitデバイスなどのハードウェアコンポーネントとの間で双方向通信が確立されます。
KrosFlo KR2i Virtual Demo Series
In this 6-part series, Julie Grace, and Carl Breuning, provide viewers with a virtual training on the KrosFlo® KR2i TFF system. This training series will cover the following topics:
- Introduction to system components
- Installation of flow-path and filter
- KF Comm2 software overview
- Recipe creation
- Running a CFC/D/C experiment
- Recovery of product
KrosFlo® KR2i Virtual Demo Series
In this 6-part series, Julie Grace, and Carl Breuning, provide viewers with a virtual training on the KrosFlo® KR2i TFF system. This training series will cover the following topics:
- Introduction to system components
- Installation of flow-path and filter
- KF Comm2 software overview
- Recipe creation
- Running a CFC/D/C experiment
- Recovery of product
AUTOMATED
Menu-driven Software for Optimized TFF
KF Comm 2 Software, backward compatible with legacy KrosFlo® KR2i and KrosFlo® KMPi Systems, is conveniently installed on any computer using the Windows Operating System. The software is compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers and is always current with automatic software and firmware updates.
- KrosFlo® TFFシステムに最適化された独自のソフトウェア
- 21 CFR Part 11オプションでGMPプロセスに対応
- 直感的なワークフローを実現する13種類の操作モード
AUTOMATED
自動背圧制御バルブ
Repligen独自の技術である自動背圧制御バルブは、あらゆるTFFプロセスに膜間差圧（TMP）制御を追加し、オペレーターの作業時間を短縮し、プロセスの再現性を向上させます。
- ユーザー定義の設定点に応じてチューブのピンチ距離を自動的に調整
- プロセス実行全体にわたって均一なTMPを維持し、膜の汚れを低減
- 精密ろ過アプリケーション中の透過圧力と流量を制御
- 対応チューブサイズ: 13、14、16、25、HP15、17、HPP24、18、HP35、36、HP36
- 入口圧力、保持液圧力、透過圧力、膜間差圧で自動的に起動
AUTOMATED
Monitor and evaluate conductivity, UV and temperature
Konduit is an add-on module ready to use with the KrosFlo® KR2i and KMPi TFF Systems, with the ability to scale from 2mL to 500L process volumes.
READY TO SCALE FAST
Scale effortlessly from Lab to Pilot Manufacturing
Transition seamlessly from small scale to larger scale processes. The KrosFlo® FS-15 handles volumes as small as 140 mL to 15 L. The KrosFlo® FS-500 is capable of larger volumes from 1.25 L to 500 L. These two KrosFlo® FS TFF Systems share common hardware architecture, software and pump technology.
- 単一のプラットフォームで拡張、縮小が可能
- 複数の用途に対して構成可能（C、D、CFC/D/C）
- Operate 21 CFR Part 11 compliant software built on secure Microsoft® SQL Server
KrosFlo® FS TFF Systems
The fully integrated KrosFlo® FS TFF System consists of hardware, software and flow path components. Key hardware components include: a diaphragm pump, auxiliary pumps and an automatic back pressure valve.
The KF Comm 2 software features a multi-language interface for complete monitoring and control and an optional 21 CFR Part 11 environment. Add tubing and sanitize/sterilize your own flow path around a Spectrum® hollow fiber filter or build a closed and gamma-irradiated ProConnex® Flow Path from over 250 components.
Click on the tabs below to explore features of the different systems.
140 mL - 15 L volume
0.1 - 0.3 m2 filtration area
KrosFlo® FS-15 compiles all the key features required for true walk-away automation and modernization of flat sheet processes from 140 mL up to 15 L, supporting membrane surface area from 0.1 - 0.3 m2. KrosFlo® FS-15 utilizes a Quattroflow™ 150 SU diaphragm pump delivering flow rates up to 3.0 liters per minute (LPM) and allowing for high pressure applications up to 4 bar.
Click on the links to explore different features.
1.25 L - 500 L volume
0.5 - 1.5 m2 filtration area
KrosFlo® FS-500 enables true walk-away automation and modernization of flat sheet processes from 1.25 L up to 500 L, supporting membrane surface area from 0.5 -1.5 m2. KrosFlo® FS-500 centers around a Quattroflow™ QF1200 SU diaphragm pump which delivers flow rates up to 18 LPM and allows for high pressure applications up to 4 bar. The KrosFlo® FS-500 design also utilizes a base plate for optimum flow path length and component geometry, as well as a permeate side flow meter.
Click on the links to explore different features.
ソリューション
Plug, play, walk away
Truly automate simple to multi-step TFF at 140 mL - 500 L and just…walk away.
コンポーネントとアクセサリ
KONDUiTは以下を追加します。
- UF/DFのエンドポイント伝導率制御
- エンドポイントUV制御で、薬物送達粒子から遊離薬物を透析ろ過
- エンドポイントUV制御で、特定の分子を濃縮
- メンブレンブレイクスルー用UVアラーム
- A260およびA280光源を利用可能
*UVコンポーネントは別売りです
トランスデューサー
- 4つの圧力を測定・表示：供給圧力、保持液圧力、透過圧力、膜間差圧（TMP）
- ユーザー定義圧力アラームとストップ設定値
- さまざまなコネクタタイプ（ルアー、TC）および選択した素材（PS、PC）で利用可能
Manufacturing Centers of Excellence
Repligenは、ISO 9001品質管理システムに基づいて、バイオ医薬品業界向けの製品を開発・製造しています。高品質で安定した、堅牢な製品をタイムリーに提供し、お客様の事業継続性を保証することを重視しています。
Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands, Germany and Estonia.
Expert Project Management
お客様第一。
サポートは、Repligenという企業の遺伝子に組み込まれています。弊社の目標は、卓越した顧客体験を提供すること、そしてRepligenの製品やサービスの適用や導入を効率よく成功に導くためにサポートすることです。
- Field Application Support
- カスタマーサービス
- フィールドサービスエンジニア
Related products
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
Process Analytics
Our process analytics solutions, featuring Variable Pathlength Spectroscopy for at-line and in-line concentration monitoring systems, ensure that products meet required Process Analytical Technology (PAT) standards. These tools provide critical data for optimizing bioprocesses and ensuring compliance with regulatory requirements.
KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
リソース
仕様
|
KrosFlo® FS-15 |
KrosFlo® FS-500 |
|
|---|---|---|
| 一般的なプロセス量 | 15L+まで | 500L+まで |
| 最大フィルター面積 | 0.3m2まで | 1.5m2まで |
| 最大圧力 | 60psi/4 barまで | |
| 流量 | 3LPMまで | 18LPMまで |
| カセットホルダー | TangenX® SIUS® PDクランプ | TangenX® SIUS®クランプ |
| リザーバー | 1L PP、ポート付き平底 | 20L PP、ポート付き平底 |
| 混合 | スケールに取り付けられた撹拌プレート | |
| TMP制御 | 非侵襲的/生成物の接触なし | |
| 補助ポンプ | KrosFlo® KRJr | KR1 |
| 流路 | ProConnex®フローパス - ポンプヘッド付シングルユース高圧フローパス | |
| ソフトウェア |
オプション 21CFR part 11パッケージ付KF Comm 2 |
|