Unmatched configurability in one integrated system

The KrosFlo KTF is configurable across parameters like filter type (hollow fiber filters and cassette), feed pump sizes, filtration area, sensors and processing volumes- giving you the flexibility to custom build a TFF system that meets your specific needs. 

Whether you’re working with shear sensitive modalities such as Lentivirus that require gentle processing or molecules like AAV that could benefit from the higher flux of a flat sheet cassette, the configurability and flexibility of the KTF system provides TFF solutions that enable you to do more.

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Enhance your capabilities while retaining a small footprint

The dual pump design of the KTF enables you to use one system for two scales of TFF operations. By utilizing both pumps together for a single application, the system delivers twice the surface area, significantly higher than other offerings within the industry. This innovative design allows you to conserve valuable square footage and avoid multiple TFF skids by leveraging one TFF system for multiple unit operations, applications, and batch sizes.  


One platform, multiple scales for unrivaled flexibility 

With volumes spanning across 1 to 5000L, you can enjoy the unrivaled flexibility of processing large and small batch sizes within the same platform as well as the consistency during scale-up.



Even more capabilities, same small footprint: KrosFlo KTF +

We’ve taken the advanced technological capabilities of our premium line of TFF systems, KrosFlo RS series, to create the next generation of KTF systems. Enjoy all the benefits of our classic KTF system now with our new recipe-based software platform.

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Software that prioritizes the user experience

The KTF + new software features an intuitive PNID-based user interface that’s designed to match the system hardware for easy navigation. The point and click editor allows users to customize and run recipes from an extensive library of pre-built recipes or to build them from scratch.


KrosFlo® KTF TFF Systems

KrosFlo KTF Systems include filters, ProConnex® Flow Path, pumps, process monitors, software and graphic display on a single skid, with a small footprint.

Click on the links below to explore different features.


ProConnex® Flow Paths for KTF

ProConnex® Flow Paths for KTF prioritize process requirements and sterility. ​These flow paths by Repligen are customized, configurable and complete assemblies for tangential flow filtration at a larger scale.  Designed for use with hollow fiber and/or flat sheet KTF configurations, the assemblies are sterile and manufactured in compliance with ISO guidelines in an ISO 7 clean room.

ProConnex® Filter Assemblies

Manufacturing Centers of Excellence

Repligenは、ISO 9001品質管理システムに基づいて、バイオ医薬品業界向けの製品を開発・製造しています。高品質で安定した、堅牢な製品をタイムリーに提供し、お客様の事業継続性を保証することを重視しています。

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.