TangenX® PRO Cassettes
Designed to be cleaned and re-used multiple times, PRO and PRO PD Reusable TFF Cassettes are interchangeable with SIUS® Single-use Cassettes.
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TangenX® PRO Reusable TFF Cassettes may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
FLEXIBLE
Diverse options for diverse process needs
PRO TFF Cassettes are offered with two membrane chemistries, two screen types, a wide selection of molecular weight cutoffs (MWCO), and a broad range of surface areas. With 96 configurations available, PRO TFF Cassettes accommodate diverse process requirements for ultrafiltration and diafiltration applications from process development to commercial manufacturing.
- Neutral charge
- 低いタンパク結合率
- Excellent chemical resistance
- 親水性
- 低いタンパク結合率
- minimal fouling with hydrophobic species
FLEXIBLE
Multiple channel configurations
Tangential flow filtration cassettes create turbulence at the membrane's surface and minimize fouling. The result is an increase in performance with a higher permeate flux. PRO Cassettes are offered in three different channel configurations to best suit the application. The channel configuration refers to the type of turbulence promoter incorporated into the feed channel of a cassette.
A medium channel or L screen is offered in all PRO Cassette formats. The screen creates turbulence at the membrane's surface ensuring outstanding permeate flux with minimal fouling. This channel configuration requires the lowest pumping rate and yields the highest cross flow velocity. This type of channel is best suited for clarified feed streams over a wide range of viscosities.
A coarser screen channel, the EP channel is offered in all PRO Cassettes. The screen geometry of this single-use cassette can process feed streams with a higher viscosity and reduce the overall pressure drop. It is scalable from 100cm2 to 2.5m2, packaged sanitized and compatible with existing cassette holders and FPIs. This type of channel is best suited for processes that use shear sensitive feed streams.
An open channel or J channel is offered in all PRO Cassettes. A 0.5mm flow spacer separating the membrane creates an open feed flow channel. This type of channel creates the least amount of turbulence while still minimizing fouling. It also requires the highest pumping rate to pass particulates. This type of channel is best suited for unclarified feed streams and is used for processes such as cell harvest operation.
FLEXIBLE
Compatible with most cassette holders
To ensure fit with cassette holders from other manufacturers,
PRO TFF Cassettes for process development are offered with two different notch patterns at the end of the cassette.
TangenX® PRO PD with standard notch
0.850in (21.59mm) Offset
このフォーマットは以下のカセットクランプおよびホルダーに適合します。
- TangenX® SIUS® PD Cassette Clamps
- TangenX® PRO PD Cassette Holders
- Pall - Centramateホルダー（CM018LV、FS001K10）
TangenX® PRO PD with offset notch
0.756インチ（19.21mm）オフセット
このフォーマットは以下のカセットクランプおよびホルダーに適合します。
- このフォーマットは以下のサードパーティ製カセットホルダーに適合します。
- Sartorius - Sartocon Sliceホルダー（17525-01、17521-02）
- GE - Kvick Labホルダー（KLPH01SSU、KLHR0105000SS）
- Millipore - Pelliconミニホルダー（XX42PMINI）
スケーラブル
プロセス開発から商業規模までスケーラブルに対応
Process volume and membrane area determine scale-up from SIUS® Single-use Cassettes to PRO Reusable TFF Cassettes.
Single-use TFF provides the greatest benefit for small to moderate scale operations.
Reusable TFF is optimal for large production scale operations.
Interested in simulating a cost model for your specific application?
TangenX® PRO Cassettes
TangenX® PRO Reusable TFF Cassettes may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
Validated for GMP use, PRO TFF Cassettes come in two industry standard format footprints with accompanying holders. They are available using ProStream or HyStream membranes, with choice of pore size and flow-channel configuration.
Click on the tabs below to explore different features of PRO Cassettes for process development or commercial manufacturing.
During process development, scientists aim to select the most promising membrane candidates, while making related decisions regarding feed pressure, TMP and screen geometry. PRO PD Cassettes enable process development scientists to select the most promising membrane candidates.
Membrane Surface Areas:
0.01 meter2, 0.02 meter2, 0.10 meter2
When the primary membrane candidate has already been chosen as a process parameter, the production method needs to be verified and production materials produced for toxicology or pre-clinical trials, and ultimately for large-scale commercial production. TangenX® PRO TFF Cassettes provide reliable cassette-to-cassette consistency, ensuring that processes can scale to commercial production levels.
Membrane Surface Areas:
0.5 meter2, 1.5 meter2, 2.5 meter2
ソリューション
TFF genius
You’re not asking for too much. Combine high selectivity and reduced processing time. Become a TFF genius and get it all with TangenX® Membranes and TFF Devices.
Manufacturing Centers of Excellence
Repligenは、ISO 9001品質管理システムに基づいて、バイオ医薬品業界向けの製品を開発・製造しています。高品質で安定した、堅牢な製品をタイムリーに提供し、お客様の事業継続性を保証することを重視しています。
Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands, Germany and Estonia.
検証済みの製造
高品質な製造
TangenX® Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate.
包括的なレギュラトリーサポートファイル
Each TangenX® TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:
- 製品情報
- カセットのデザイン
- 素材
- 製品の性能
- 安全に関する情報
- 文書化システム
- 製品の製造
- 資格証明
- 製造プロセスの検証
- リリーステスト
お客様第一。
サポートは、Repligenという企業の遺伝子に組み込まれています。弊社の目標は、卓越した顧客体験を提供すること、そしてRepligenの製品やサービスの適用や導入を効率よく成功に導くためにサポートすることです。
- Field Application Support
- カスタマーサービス
- フィールドサービスエンジニア
TangenX® PRO Hardware
TX003（パイロットホルダー）
- 0.01～0.5 m2（1～5 ft2）のスクリーンチャンネルカセット、吊り下げスクリーンチャンネルカセットに適合
- ホールドアップボリュームを減らせるルアーロック、サニタリー用途向けのミニトライクランプ継手で利用可能
TX034（スタンド、3-ゲージフィッティングパッケージ付きHC-LHVホルダー）
- 排水性の向上
- 設置面積が小さく、限られた実験室スペースの有効利用が可能
TX032 （水平サニタリーホルダーバージョン2）
- 0.46～6 m2（%～50 ft2）のスクリーンチャンネルカセット、吊り下げスクリーンチャンネルカセットに適合
- 設置面積が小さいため、資本コスト、運用コストが軽減され、限られた生産スペースを効率的に使用できます
TX005（自動トルク付き垂直衛生ホルダー)
- 排水性の向上
- 油圧式、自動トルククロージングオプションが利用可能
- 面積が広いシステムのロードに伴う難しさと時間を最小化
- カセットのミスアライメント、漏れを防止
- 片面、縦型デザインで、カセットの取り付けや交換が容易
- オペレータによるトルク変動を排除
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KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
TangenX® SIUS® TFF Cassettes
SIUS® Cassettes are the first purpose-built single-use cassettes for tangential flow filtration, delivering unparalleled savings in filter cost, labor cost and buffer use.
TangenX SC TFF Device
TangenX® SC TFF Device: Revolutionize tangential flow filtration processes
Eliminate the hassle and inefficiency that comes with traditional downstream filtration cassette formats. Say goodbye to cassette holders, complex setups, continued torquing, wasted time, and product loss risks. Discover TangenX® SC, the future of TFF cassette solutions for ultrafiltration and diafiltration, designed to meet the demands of today’s TFF processes while dramatically reducing setup time and minimizing product loss risk.
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