SoloVPE Application: Plasmid DNA Purity

Measure Plasmid Purity With Unsurpassed Accuracy

The purest assessment you can get

The emergence of different high absorbance biotherapeutics modalities, such as oligonucleotides, presents a challenge in using traditional spectrophotometric methods for concentration measurements.  Slope Spectroscopy^® offers an excellent alternative to traditional spectrophotometric analysis for nucleic acid quantitation and purity assessment using A260/A280 ratio measurement.

The SoloVPE Solution

• Accurately measures DNA and plasma purity undiluted. 
• Eliminates the need for baseline and scatter correction. 
• Allows users to get an accurate R²  value by measuring the 260 nm and 280 nm wavelength simultaneously. 
• Manipulates Beer’s law, allowing the System to accurately vary the absorbance with the change in pathlength.
• Simultaneous wavelength measurement enables automated calculation of absorbance ratio.  
• There is no sample handling or sample prep, just direct measurement, while the variable pathlength allows R²  of ≥0.999. 
• The MultiQ feature allows users to measure 260 nm and 280 nm simultaneously.

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