TangenX® SIUS® TFF Cassettes
SIUS® Cassettes are the first purpose-built single-use cassettes for tangential flow filtration, delivering unparalleled savings in filter cost, labor cost and buffer use.
TangenX® SIUS® Cassettes
Validated for GMP use, SIUS® TFF Cassettes are delivered ready to use with either ProStream or HyStream membranes, with choice of pore sizes and flow-channel configurations. Pre-sanitized and packaged with 0.2M NaOH, the cassettes are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
Click on the tabs below to explore different features of SIUS Cassettes for process development or commercial manufacturing.
During process development, the aim is to select the most promising membrane candidates while making related decisions regarding feed pressure, transmembrane pressure (TMP) and screen geometry. SIUS® PD single-use TFF Cassettes save valuable time and resources by eliminating cleaning cycles between experiments. Designed for processing volumes from tens of milliliters to several liters, SIUS PD Cassettes enable linear scale processing over a wide range of operating volumes.
Membrane Surface Areas:
0.01 m2, 0.02 m2, 0.10 m2
When the primary membrane candidate has already been chosen as a process parameter, the production method needs to be verified and production materials produced for toxicology or pre-clinical trials, and ultimately for large-scale commercial production. SIUS® Single-use TFF Cassettes provide reliable cassette-to-cassette consistency, ensuring that processes can scale to commercial production levels.
Membrane Surface Areas:
0.5 m2, 1.5 m2, 2.5 m2
TangenX® SIUS® Single-use TFF Cassettes are a convenient alternative to reusable cassettes. Delivered ready to use with choice of membrane, pore size and flow-channel configuration, SIUS Cassettes enable cost and process efficiencies while eliminating tedious clean-in-place (CIP) and sanitization steps because increased labor and consumables are not required.
SINGLE-USE EFFICIENCY
Unparalleled process and cost efficiencies
TangenX® SIUS® Single-use Cassettes are the first purpose-built cassettes designed for tangential flow filtration. Deploying these innovative cassettes can help reduce filter cost by 80%, reduce labor costs by 50%, and reduce buffer and water usage by 75% when compared to traditional reusable cassettes.
HIGH PERFORMANCE UF/DF
Solutions designed to meet the needs of your process
SIUS® TFF Cassettes are offered with two membrane chemistries, two screen types and an open channel, a wide selection of molecular weight cutoffs (MWCO), and a broad range of surface areas. SIUS TFF Cassettes accommodate diverse process requirements for ultrafiltration and diafiltration applications from process development to commercial manufacturing.
| TangenX® SIUS® PD Cassettes | TangenX® SIUS® Cassettes | |
|---|---|---|
| 構成 | シングルユースの | |
| Membrane chemistry | ProStream, HyStream | |
| MWCO | 1 kD*, 3 kD*, 5 kD, 10 kD, 30 kD, 50 kD, 100 kD, 300 kD, 0.1 µm±, 0.2 µm±, 0.45 µm±, 0.65 µm± | |
| Holder | TangenX / Pall / Millipore / GE / Sartorius | ユニバーサル |
| Membrane Area | 0.01, 0.02, 0.10 m2 | 0.5, 1.5, 2.5 m2 |
| Channel type | L, E, J | |
| *ProStream membrane only ±HyStream membrane only | ||
- Neutral charge
- 低いタンパク結合率
- Excellent chemical resistance
- 親水性
- 低いタンパク結合率
- Minimal fouling with hydrophobic species
- L Screen (low viscosity)
- E Screen (high viscosity)
- J Open Channel
FLEXIBLE
Multiple channel configurations
Turbulence at the membrane surface minimizes fouling. The result is an increase in performance with a higher permeate flux. SIUS® Cassettes are offered in three different channel configurations to best suit the application. The channel configuration refers to the type of turbulence promoter incorporated into the feed channel of a cassette.
A medium channel or L-screen is offered in all TangenX SIUS cassette formats. The screen creates turbulence at the membrane's surface ensuring outstanding permeate flux with minimal fouling. This channel configuration requires the lowest pumping rate and yields the highest cross flow velocity. This type of channel is best suited for clarified feed streams over a wide range of viscosities.
A coarse screen, the E-screen is offered in all TangenX SIUS cassettes. The screen geometry of this single-use cassette can process feed streams with a higher viscosity and reduce the overall pressure drop. It is scalable from 100 cm2 to 2.5 m2, packaged, sanitized and compatible with existing cassette holders and FPIs. This type of channel is best suited for processes with viscous, high concentration feed streams.
An open channel or J channel is offered in all TangenX SIUS cassettes. A 0.5 mm flow spacer separating the membrane creates an open feed flow channel. This type of channel creates the least amount of turbulence while still minimizing fouling. It also requires the highest pumping rate to pass particulates. This type of channel is best suited for unclarified feed streams and is used for processes such as cell harvest operation.
FLEXIBLE
Compatible with most cassette holders
To ensure fit with cassette holders from other manufacturers, SIUS® PD TFF Cassettes for process development are offered with two different notch patterns at the end of the cassette.
TangenX® SIUS® PD with standard notch
0.850in (21.59mm) Offset
このフォーマットは以下のカセットホルダーに適合します。
- TangenX® SIUS® PD Cassette Clamps
- Pall Centramate Cassette Holders
TangenX® SIUS® PD with offset notch
0.756インチ（19.21mm）オフセット
This cassette format is compatible wiht holders from:
- Merck Millipore
- Sartorius
スケーラブル
プロセス開発から商業規模までスケーラブルに対応
Scalable from process development to commercial manufacturing volumes.
Single-use TFF provides the greatest benefit for small to moderate scale operations.
Reusable TFF is optimal for large production scale operations.
Interested in simulating a cost model for your specific application?
ソリューション
TFF genius
You’re not asking for too much. Combine high selectivity and reduced processing time. Become a TFF genius and get it all with TangenX® Membranes and TFF Devices.
Manufacturing Centers of Excellence
Repligenは、ISO 9001品質管理システムに基づいて、バイオ医薬品業界向けの製品を開発・製造しています。高品質で安定した、堅牢な製品をタイムリーに提供し、お客様の事業継続性を保証することを重視しています。
Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands, Germany and Estonia.
Validated manufacturing
高品質な製造
TangenX® Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate.
包括的なレギュラトリーサポートファイル
Each TangenX® TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:
- 製品情報
- カセットのデザイン
- 素材
- 製品の性能
- 安全に関する情報
- 文書化システム
- 製品の製造
- 資格証明
- 製造プロセスの検証
- リリーステスト
SINGLE-USE EFFICIENCY
Simple connectivity with ProConnex® Flow Paths
Custom ProConnex® Flow Paths complete your TFF solution. Flow paths are built using Class VI bioprocess-grade materials that are BSE/TSE-free and lot-traceable.
SIUS® Hardware
TSLDI-2BMC（クランプ）
TFPLS-SA08（フィルタープレート）
TSPDI-4BMC（クランプ）
TFP75-SE16（フィルタープレート）
お客様第一。
サポートは、Repligenという企業の遺伝子に組み込まれています。弊社の目標は、卓越した顧客体験を提供すること、そしてRepligenの製品やサービスの適用や導入を効率よく成功に導くためにサポートすることです。
- Field Application Support
- カスタマーサービス
- フィールドサービスエンジニア
KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
TangenX SC TFF Device
TangenX® SC TFF Device: Revolutionize tangential flow filtration processes
Eliminate the hassle and inefficiency that comes with traditional downstream filtration cassette formats. Say goodbye to cassette holders, complex setups, continued torquing, wasted time, and product loss risks. Discover TangenX® SC, the future of TFF cassette solutions for ultrafiltration and diafiltration, designed to meet the demands of today’s TFF processes while dramatically reducing setup time and minimizing product loss risk.
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