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XCell® ATF Devices and Controllers

XCell® ATF Systems simplify and fast-track upstream intensification by providing an integrated solution consisting of an XCell® ATF Device, XCell® ATF Controller, software, tubing, pressure sensors and accessories. The family of Systems supports diverse applications across development from 1L to 5000 L.

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XCell® ATF Device Size Selection Guide

Presented are hollow fiber filter areas, XCell® ATF Pump volumes, and typical bioreactor working volumes paired with each XCell ATF Device. Actual capacity and vessel size depend upon specific cell culture process conditions.

デバイスEffective filter surface area (m2) Approximate ATF volume exchanged (L) Suspension cultures volume (L)
XCell ATF 10.022 0.017 0.5～2
XCell ATF 20.13 0.1 2～10
XCell ATF 40.77 0.4 10～50
XCell ATF 6 2.5 1.3 50～200
XCell ATF 10 11.0 6.0 200～5000

XCell® ATF Single-use Devices

XCell ATF 1 Single-use Device

XCell ATF 2 Single-use Device

XCell ATF 6 Single-use Device

XCell ATF 10 Single-use Device

XCell ATF Single-use Tubing Sets

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フィルターのウェッティング手順

XCell ATF Single-use Devices are supplied dry. To ensure robust filter performance, it is important to wet the filter prior to use.  The XCell ATF Tubing Set and the suggested wetting protocols are designed to:

  • ウェッティングプロセス中のエアポケット形成を最小限に抑えることで、効率的かつ完全なフィルターウェッティングが可能
  • 無菌性を維持しつつ、使用前フィルターの完全性テストが可能
  • Provide a means for evaluating the sterility of the XCell ATF device prior to establishing the bioreactor connection
  • Allow change-out of the XCell ATF device during a cell culture run without interrupting the bioreactor or XCell ATF operation

 

XCell ATF Stainless Steel Devices

XCell ATF 2 Stainless Steel Device

XCell ATF 4 Stainless Steel Device

XCell ATF 6 Stainless Steel Device

XCell ATF 10 Stainless Steel Device

中空糸フィルターの取付方法

Watch the video on how to install a hollow fiber filter into an XCell ATF 10 stainless steel device.

 

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XCell® Controllers

XCell Lab Controller

   for use with:
XCell ATF 1 (SU)
XCell ATF 2 (SU,SS)
XCell ATF 4 (SS)

XCell LS Controller

for use with:
XCell ATF 4 (SS)
XCell ATF 6 (SU, SS)
XCell ATF 10 (SU, SS)

 

XCell C410 Controller

for use with:
XCell ATF 4 (SS)
XCell ATF 6 (SU, SS)
XCell ATF 10 (SU, SS)

XCell C410 Controller Cart​
(optional)

Advancing Upstream Intensification Through Partnership

Repligen has partnered with Sartorius to integrate the XCell® ATF large scale controller technology into the Biostat 3G STR® bioreactor to advance Upstream Intensification for biopharmaceutical manufacturers. 

 

Read more

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XCell ATF devices by scale

  XCell® ATF 1 Single-use Device XCell® ATF 2 Single-use Device XCell® ATF 4 Stainless Steel Device
 

XCell® ATF 1

XCell® ATF 2

XCell® ATF 4
Typical Bioreactor size (L) 0.5～2 2～10 10～50
Format SU SU, SS SS
Chemistry PES PES, PS PES, PS
Typical pore size SU 0.2µ 0.2µ 0.2µ
Typical pore size SS NA 0.2µ, 0.5µ, 50KDa 0.2µ, 0.5µ, 50KDa
Effective surface area (m2) 0.022 0.13 0.77
Filter height (cm) 60 60 30
Displacement volume (L) 0.017 0.1 0.4
ATF flow range (Lpm) 0.008～0.140 0.4 - 1.5 3～8
Typical scalable flow/fiber and filtrate rate 12 mL/min/fiber and 4-6 LMH
コントローラー XCell Lab Scale Controller
  • XCell Lab Scale Controller
  • XCell C410 Controller
  • XCell LS Controller
  XCell® ATF 4 Stainless Steel Device XCell® ATF 6 Single-use Device
 

XCell® ATF 4

XCell® ATF 6
Typical Bioreactor size (L) 10～50 50～200
Format SS SU, SS
Chemistry PES, PS PES, PS
Typical pore size SU 0.2µ 0.2µ
Typical pore size SS 0.2µ, 0.5µ, 50KDa 0.2µ, 0.5µ, 50KDa
Effective surface area (m2) 0.77 2.5
Filter height (cm) 30 60
Displacement volume (L) 0.4 1.3
ATF flow range (Lpm) 3～8 10～20
Typical scalable flow/fiber and filtrate rate  
コントローラー
  • XCell Lab Scale Controller
  • XCell C410 Controller
  • XCell LS Controller
  • XCell C410 Controller
  • XCell LS Controller
  XCell® ATF 6 Single-use Device XCell® ATF 10 Single-use Device
 

XCell® ATF 6

XCell® ATF 10
Typical Bioreactor size (L) 50～200 200～5000
Format SU, SS SU, SS
Chemistry PES, PS PES, PS
Typical pore size SU 0.2µ 0.2µ
Typical pore size SS 0.2µ, 0.5µ, 50KDa 0.2µ, 0.5µ, 50KDa
Effective surface area (m2) 2.5 11
Filter height (cm) 60 60
Displacement volume (L) 1.3 6
ATF flow range (Lpm) 10～20 30～80
Typical scalable flow/fiber and filtrate rate 12 mL/min/fiber and 4-6 LMH 12 mL/min/fiber and 4-6 LMH
コントローラー
  • XCell C410 Controller
  • XCell LS Controller
  • XCell C410 Controller
  • XCell LS Controller

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