KrosFlo® KR2i TFF System
Single-use fully integrated benchtop TFF system for research and process development (PD) ranging from 2mL - 15L. Compatible with hollow fiber and flat sheet filters, this system features a peristaltic feed pump with 13 automated process modes.
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Robust Processing
Ultrafiltration and diafiltration (UF/DF) processing for batch volumes ranging 2mL to 15L.
使いやすい
Plug and play configurability to add and remove components as needed with minimal effort.
Compatible with flat sheet cassettes and hollow fiber filters.
Walk-away automation
13 automated process control modes with the Automatic Back Pressure Valve (ABV) and intuitive software platform.
Off-the-shelf flow paths
Gamma irradiated, single-use, ProConnex® flow paths for enhanced reproducibility, time savings and sterility.
Modularity Made Easy with Plug-and-Play Configurability
KrosFlo® KR2i TFF systems achieve an unparalleled combination of configurability and user-simplicity through modular, plug-and-play hardware. All components, either directly or indirectly, connect to the main pump, which then communicates with the KF Comm 2 software for control and monitoring.
More Capabilities, Still Simple.
Get more out of TFF with the flexibility to configure your system to better suit your application needs. Keep your process compact and minimal or expand your capabilities to more advance modes of operation by adding components. Switch back and forth between configurations all without compromising on ease of use.
Automate, Control and Visualize with KF Comm 2
Control the whole system, configure recipes and automate processes in as little as 4 clicks through the intuitive KF Comm 2 software.
- Conveniently installed on any device using the Windows Operating System
- Compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers
- Automatic software and firmware updates
- Optional 21 CFR Part 11 package available
従来のKF Commソフトウェアを使用していますか？ Upgrade now
Walk-away automation for your lab
The days of manually adjusting screw clamps are over. A Repligen-exclusive technology, the Automatic Back Pressure (ABV) Valve adds transmembrane pressure (TMP) control to every TFF process, reducing operator hands-on-time, data logging and continuous monitoring while improving process reproducibility.
- Automatically adjust tubing pinch distance according to user-defined set-points
- Maintain uniform TMP throughout process run, decreasing membrane fouling
- 対応チューブサイズ: 13、14、16、25、HP15、17、HPP24、18、HP35、36、HP36
インラインタンパク質濃度管理が可能なTFF
No longer are you dependent solely on mass inputs and off-line fixed-pathlength UV-Vis spectrophotometers. Now, you can measure what truly matters in real-time with the KrosFlo® KR2i RPM™ System. Monitor concentration in real time during your UF/DF run and control your process.
KrosFlo KR2i Virtual Demo Series
In this 6-part series, Julie Grace, and Carl Breuning, provide viewers with a virtual training on the KrosFlo® KR2i TFF system. This training series will cover the following topics:
- Introduction to system components
- Installation of flow-path and filter
- KF Comm2 software overview
- Recipe creation
- Running a CFC/D/C experiment
- Recovery of product
KrosFlo® KR2i Virtual Demo Series
Whether you’re new to this TFF system or in need of a refresher, this virtual demo series will show how easy it is to set up and operate a KrosFlo KR2i. This training series will cover the following topics:
- Introduction to system components
- Installation of flow-path and filter
- KF Comm2 software overview
- Recipe creation
- Running a CFC/D/C experiment
- Recovery of product
Standard and Configurable ProConnex® Flow Paths
ProConnex® Flow Paths are customized, configurable and complete assemblies for tangential flow filtration. Designed for use with hollow fiber and/or flat sheet TFF systems, the assemblies are sterile, fit for upstream or downstream processing and manufactured in compliance with ISO guidelines in an ISO 7 clean room.
Effortless scaling with a single standardized platform
Designed as a platform and not as standalone units, KrosFlo KR2i, KMPi, and FS lab scale TFF systems share the same components, software and controls across the entire family, allowing you to confidently standardize your process. Common process change challenges during scale-up are removed.
System features at a glance
The fully integrated KrosFlo KR2i TFF System features a digital peristaltic pump, graphical LCD display, digital pressure monitor, KR2i Pump head, automatic backpressure valve, filter module stand, and KF Comm real-time data collection software.
Highly configurable and versatile, the KrosFlo KR2i utilizes a number user-defined set-points to run complex application processes with numerous built-in safety alarms and stops. The system can run up to two stackable pump heads for higher flow rates.
Click on the links below to explore different features.
コンポーネントとアクセサリ
- IP 33エンクロージャー
- リバーシブルドライブ付き600 RPMポンプ
- 90-260 Vrms @ 50/60 Hz
- 精密チューブ用の標準Easy Load 3ポンプヘッド L/S番号13、14、16、25、17、18を提供しています。
- （オプション）高性能チューブ用Easy Load 3ポンプヘッド L/S番号15、24、35、36
- ETL（北米安全認証）取得済み、およびCE/UL/cULマーク付き
- ポンプドライブの寸法: 10.5インチ x 8インチ x 8インチ
KONDUiTは以下を追加します。
- UF/DFのエンドポイント伝導率制御
- エンドポイントUV制御で、薬物送達粒子から遊離薬物を透析ろ過
- エンドポイントUV制御で、特定の分子を濃縮
- メンブレンブレイクスルー用UVアラーム
- A260およびA280光源を利用可能
*UVコンポーネントは別売りです
トランスデューサー
- 4つの圧力を測定・表示：供給圧力、保持液圧力、透過圧力、膜間差圧（TMP）
- ユーザー定義圧力アラームとストップ設定値
- さまざまなコネクタタイプ（ルアー、TC）および選択した素材（PS、PC）で利用可能
Related products
KrosFlo® KTF TFF Systems
The KrosFlo KTF are a series of highly configurable single-use TFF systems for multiple unit operations, applications, and filter types. With volumes spanning across 1 to 5000L, users enjoy the unrivaled flexibility of processing large and small batch sizes within the same platform.
KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
Process Analytics
Our process analytics solutions, featuring Variable Pathlength Spectroscopy for at-line and in-line concentration monitoring systems, ensure that products meet required Process Analytical Technology (PAT) standards. These tools provide critical data for optimizing bioprocesses and ensuring compliance with regulatory requirements.
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